2025-05-21
Revolutionizing Label-Free Protein Detection: OptoSeeker-Powered Breakthrough Achieves 15-Minute Assays
In medical diagnostics and disease management, rapid and accurate protein biomarker detection is critical. Conventional methods like ELISA offer accuracy but suffer from lengthy procedures (2-3 hours), operational complexity, and high costs. Professor Zhang Shuailong and Fu Rongxin’s team at Beijing Institute of Technology recently unveiled a breakthrough in Nano Letters: an electroosmotic-driven digital optofluidics (e-DOF) platform. This innovation quantifies protein-binding nanoscale deformations via hyperspectral interferometry, slashing detection time to 15 minutes with 0.21 nM sensitivity (50× improvement over ELISA) and 100% clinical accuracy.
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